Lazio are still unbeaten in Serie A under Edy Reja, but visit an increasingly desperate Catania side.
It kicks off at 11.30 GMT, click here for a match preview.
Reja managed to stall Roma’s progress in the Derby della Capitale and has not lost a League game since replacing Vladimir Petkovic over Christmas.
The pressure is also on to rotate the squad ahead of their Europa League match with Ludogorets on Thursday.
Helder Postiga, Bruno Pereirinha and Ederson are out of action, while Etrit Berisha again stands in for the not 100 per cent fit Federico Marchetti in goal.
Stefano Mauri gets his first start since May’s Coppa Italia Final, having made his comeback from a betting-related ban last weekend.
Lucas Biglia also returns after a one-game suspension to bolster the midfield.
Catania are still bottom of the table, but have certainly improved of late with three consecutive draws, including last week’s unlucky stalemate at Parma.
The return of Francesco Lodi on loan from Genoa helped the Elefantini rediscover their form and he is again pulling the midfield strings today.
Alberto Frison, Sergio Almiron and Sebastian Leto are out of action, so Argentina international Mariano Andujar takes the gloves.
Coach Rolando Maran was sacked, then recalled after a poor spell under Gigi De Canio.
Catania: Andujar; Peruzzi, Bellusci, Spolli, Alvarez; Izco, Lodi, Rinaudo; Barrientos, Bergessio, Castro
Catania bench: Ficara, Capuano, Legrottaglie, Rolin, Gyomber, Biraghi, Monzon, Plasil, Boateng, Fedato, Keko, Petkovic
Lazio: Berisha; Konko, Biava, Dias, Radu; Ledesma, Biglia; Candreva, Mauri, Lulic; Klose
Lazio bench: Marchetti, Strakosha, Cana, Ciani, Cavanda, Crecco, Gonzalez, Onazi, Felipe Anderson, Kakuta, Keita, Perea