Week 25 is staggered from Saturday to Monday, including Bologna-Roma, Napoli-Genoa, Sampdoria-Milan and the Turin Derby.
It all begins this evening at the Stadio Dall’Ara when second-placed Roma visit Davide Ballardini’s revived Bologna.
On Sunday the early kick-off is Livorno-Verona, while in the afternoon Inter host Cagliari and Clarence Seedorf faces his former teammate Sinisa Mihajlovic as Milan take on Sampdoria.
Chievo-Catania is a relegation dogfight and Udinese-Atalanta is a battle not to join them in the race against the drop.
At the unusual kick-off time of 17.30 GMT on Sunday, Juventus face Torino in what could well be the most evenly-matched Derby della Mole for decades.
Tomorrow evening Lazio try to end their crisis against Domenico Berardi’s Sassuolo.
The teams who played their Europa League ties away from home will be in action on Monday, as Parma-Fiorentina and Napoli-Genoa promise intriguing fixtures.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!