Today sees Milan visit Sampdoria and Inter host Cagliari, but all eyes are on Juventus-Torino for the Derby della Mole.
Click here for all the individual match previews for Serie A Week 25, plus the report from Saturday’s Bologna-Roma encounter.
It begins at 11.30 GMT with a revived Livorno welcoming high-flying Hellas Verona.
At 14.00 GMT Clarence Seedorf has an extremely difficult test away to his former Samp teammate Sinisa Mihajlovic, while Inter try to build on their momentum against chaotic Cagliari.
Chievo-Catania and Udinese-Atalanta are important relegation battles.
At the unusual kick-off time of 17.30 GMT, Juventus and Torino go head-to-head in what could well be the most evenly-matched Derby della Mole in decades.
This evening Lazio and Sassuolo are both desperate to emerge from crisis situations.
The round concludes on Monday with an intriguing Parma-Fiorentina for Europe and Napoli-Genoa.