Clarence Seedorf is forced to reshuffle his Milan side against old teammate Sinisa Mihajlovic’s Sampdoria.
It kicks off at Marassi at 14.00 GMT, click here for a match preview.
These two tacticians were Sampdoria teammates in 1995-96 and now find themselves as Serie A Coaches jostling for position.
Only four points separate them going into this game and the Rossoneri are struggling for momentum, following a 1-0 win over Bologna with a home defeat to Atletico Madrid midweek.
The injury list has grown even more extensive over the last few days, ruling out Christian Abbiati, Mario Balotelli, Mattia De Sciglio, Robinho, Stephan El Shaarawy, Cristian Zapata, Valter Birsa, Matias Silvestre and Bryan Cristante.
Daniele Bonera is a late addition to that group, as he apparently picked up the same bug Abbiati is suffering from last night, so Cristian Zaccardo steps into an all-new back four.
Keisuke Honda, Riccardo Saponara, Sulley Muntari and Riccardo Montolivo start, as they were unable to feature in the Champions League on Wednesday night.
Marco Amelia is given the nod in goal with Kevin Constant at left-back and Giampaolo Pazzini starting against his former club.
Sampdoria had been doing very well under Mihajlovic, but he vented his frustration at the team for their 3-0 defeat to Roma last week.
Lorenzo De Silvestri and Daniele Gastaldello picked up bans, so he moves ex-Manchester United youth team player Michele Fornasier to right-back.
Eder again leads the attack supported by Manolo Gabbiadini, Pawel Wszolek and Nenad Krsticic.
Sampdoria: Da Costa; Fornasier, Mustafi, Regini, Costa; Palombo, Obiang; Gabbiadini, Kristicic, Wszolek; Eder
Sampdoria bench: Fiorillo, Falcone, Berardi, Salamon, Rodriguez, Renan, Bjarnason, Sestu, Soriano, Sansone, Okaka, Maxi Lopez
Milan: Amelia; Abate, Zaccardo, Rami, Constant; Montolivo, Muntari; Honda, Saponara, Taarabt; Pazzini
Milan bench: Gabriel, Coppola, Mexes, Emanuelson, Essien, De Jong, Poli, Kakà, Petagna