Juventus host Torino in the Derby della Mole with Carlos Tevez and Fernando Llorente against Ciro Immobile and Alessio Cerci.
It kicks off at the unusual time of 17.30 GMT, click here for a match preview.
This could be the most evenly-matched Turin Derby for decades, as the Granata are in joint sixth place and have nothing to lose.
Immobile – co-owned by Juventus – and Cerci have netted 24 Serie A goals between them this season.
Omar El Kaddouri is on loan from Napoli and is in midfield with Jasmin Kurtic, while Cesare Bovo is preferred to Nikola Maksimovic.
Salvatore Masiello was in the starting XI, but is replaced by Giovanni Pasquale after suffering an injury during the warm-up.
On the other hand, the Bianconeri are without the injured Giorgio Chiellini, Mirko Vucinic and Simone Pepe, though Andrea Barzagli returns to the back three after a calf problem.
Martin Caceres is preferred to Angelo Ogbonna despite being more of a full-back.
They risk fatigue after Thursday’s 2-0 Europa League victory over Trabzonspor and have to consider squad rotation ahead of next week’s second leg in Turkey.
Nonetheless, there is no rest for Tevez and Llorente, who have between them scored 23 Serie A goals.
Andrea Pirlo pulls the midfield strings with Paul Pogba and Arturo Vidal.
Torino haven’t won this fixture since a Ruggiero Rizzitelli brace in April 1995 and haven’t even scored for 12 years.
Juve have conceded in their last six Serie A games, whereas Toro kept five clean sheets during the same period.
Juventus: Buffon; Barzagli, Bonucci, Caceres; Lichtsteiner, Vidal, Pirlo, Pogba, Asamoah; Llorente, Tevez
Juventus bench: Storari, Rubinho, Isla, Ogbonna, Peluso, Padoin, Marchisio, Giovinco, Osvaldo, Quagliarella
Torino: Padelli; Bovo, Glik, Moretti; Darmian, Kurtic, Vives, El Kaddouri, Pasquale; Cerci, Immobile
Torino bench: Gomis, Berni, Rodriguez, Basha, Farnerud, Gazzi, Larrondo, Maksimovic, Vesovic, Meggiorini, Tachtsidis