Napoli have Gonzalo Higuain, Jose Callejon, Goran Pandev and Lorenzo Insigne, as they must beat Swansea.
The Europa League Round of 32 tie kicks off at the Stadio San Paolo at 18.00 GMT, the first leg ended 0-0 at the Liberty Stadium.
This means a score draw would be enough to send Swansea through to the next round on the away goals rule.
Despite the disappointing performance in defence last time out, Rafa Benitez has stuck with Henrique and Raul Albiol at centre-back.
Pepe Reina is in goal, as second choice Rafael is out for six months after rupturing knee ligaments in the first leg.
Jorginho is not on the UEFA list, while Insigne, Pandev and Callejon fan out behind Higuain, so Dries Mertens and Marek Hamsik are on the bench.
Swansea are without star striker Michu and Jonjo Shelvey, but Wilfried Bony hopes to again use his pace against the Napoli back four.
Napoli: Reina; Maggio, Henrique, Albiol, Ghoulam; Inler, Behrami; Insigne, Pandev, Callejon; Higuain
Napoli bench: Colombo, Reveillere, Britos, Hamsik, Dzemaili, Mertens, Zapata
Swansea: Vorm; Tiendalli, Williams, Chico, B Davies; Canas, De Guzman; Routledge, Emnes, Pablo Hernandez; Bony
Swansea bench: Tremmel, Amat, Taylor, Rangel, Pozuelo, Dyer, Ngog
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more