Domenico Berardi and Alessio Romagnoli are in the Italy Under-21 side to face Northern Ireland on March 5.
This is a qualifier for the European Under-21 Championships and will be played in Lurgan on Tuesday at 16.00 GMT.
Sassuolo star Berardi is included after an impressive 12 Serie A goals so far this season, while Roma defender Romagnoli is a new face for Coach Gigi Di Biagio.
Bans rule out Sassuolo defender Luca Antei, Catania left-back Cristiano Biraghi and Atalanta midfielder Daniele Baselli.
Italy are currently third in their group behind Belgium and Serbia.
GK: Bardi (Livorno), Leali (Spezia), Perin (Genoa)
D: Bianchetti (Spezia), Ceccherini (Livorno), Chiosa (Bari), De Col (Virtus Lanciano), Murru (Cagliari), Romagnoli (Roma), Rugani (Empoli), Sabelli (Bari)
M: Battocchio (Watford), Benassi (Livorno), Cataldi (Crotone), Crisetig (Crotone), Dezi (Crotone), Molina (Modena), Viviani (Latina)
F: Belotti (Palermo), Berardi (Sassuolo), Bernardeschi (Crotone), Comi (Virtus Lanciano), Trotta (Brentford)
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!