Juventus visit Milan this evening in a huge fixture and Fiorentina host troubled Lazio, while Napoli are in action in Livorno.
Click here for all the individual match previews from Serie A Week 26, plus the report from a controversial Roma-Inter.
It all begins at 11.30 GMT with Cagliari-Udinese, two teams who are in the balance between safety and the danger zone.
This afternoon there’s Torino-Sampdoria, high-flying Verona against Bologna, Atalanta-Chievo and Genoa-Catania.
At the unusual kick-off time of 17.30 GMT, Napoli are in action away to a revived Livorno, but must do without Gonzalo Higuain.
At 19.45 GMT we see off the round with two big fixtures, as leaders Juventus take on Clarence Seedorf’s Milan and Fiorentina host struggling Lazio.