Napoli have the opportunity to close the gap on Roma and Juventus, but are without Gonzalo Higuain in Livorno.
It kicks off at 17.30 GMT, click here for a match preview.
Rafa Benitez must do without the suspended Higuain and Raul Albiol, while Rafael Cabral, Giandomenico Mesto and Juan Camilo Zuniga are injured.
Goran Pandev takes the centre-forward role backed by Jose Callejon and Dries Mertens, while Jorginho returns after he was cup-tied for Thursday’s 3-1 Europa League victory over Swansea.
Roma were held to a 0-0 draw by Inter last night, so Napoli have the chance to close the gap on second place.
It’s an opportunity they cannot afford to let slip after last week’s surprise 1-1 home draw to Genoa.
Livorno won’t make life easy for the Partenopei, as they have recently rediscovered their form under new Coach Domenico Di Carlo.
Luca Siligardi and captain Andrea Luci are injured, but Paulinho and Ishak Belfodil, who is on loan from Inter, form the attack.
However, Livorno’s last home victory over Napoli in Serie A was back in 1947-48.
Livorno: Bardi; Ceccherini, Emerson, Coda; Mbaye, Benassi, Biagianti, Greco, Mesbah; Paulinho, Belfodil
Livorno bench: Anania, Aldegani, Rinaudo, Valentini, Gemiti, Castellini, Piccini, Duncan, Mosquera, Emeghara, Hernandez
Napoli: Reina; Maggio, Fernandez, Britos, Ghoulam; Inler, Jorginho; Mertens, Hamsik, Callejon; Pandev
Napoli bench: Contini, Colombo, Henrique, Reveillere, Radosevic, Behrami, Bariti, Dzemaili, Insigne, Zapata
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