It’s a decisive round for the season, as Juventus host old rivals Fiorentina and tonight second-placed Roma visit Napoli.
Click here for individual previews of every single Serie A Week 27 match, plus reports on Saturday’s Udinese-Milan and Catania-Cagliari.
The action begins with a huge fixture at 11.30 GMT, as Juve face the only team able to beat them in Serie A this term.
It’s also an age-old grudge match with Fiorentina and they’ll battle again on March 13 and 20 in the Europa League Round of 16.
This afternoon Inter-Torino and Parma-Verona are head-to-head showdowns for a place in Europe, while Bologna-Sassuolo and Sampdoria-Livorno are key to safety.
At 19.45 GMT third-placed Napoli take on second-placed Roma as they go toe-to-toe for that automatic Champions League spot.
These sides met in the Coppa Italia semi-final last month and the Partenopei went through 5-3 on aggregate, losing 3-2 in Rome and winning 3-0 at the San Paolo.