Juventus rotate the squad and face a difficult trip to Gian Piero Gasperini’s Genoa, losing two players at the last minute.
It kicks off at Marassi at 19.45 GMT, click here for a match preview.
The Bianconeri will need absolute concentration this evening, as they are 14 points clear at the top of the Serie A table and in-between Europa League Round of 16 games with Fiorentina.
They drew 1-1 in Turin in the first leg, so the attention of the players is already on next Thursday night in Florence.
Carlos Tevez, Claudio Marchisio, Sebastian Giovinco, Mirko Vucinic and Simone Pepe are injured.
It means Daniel Osvaldo starts with Fernando Llorente, while Paul Pogba returns in midfield.
Andrea Barzagli was named in the starting XI, but pulled out in the warm-up with a calf problem, so Giorgio Chiellini will play instead.
Federico Peluso was also sent back to Turin after coming down with flu symptoms.
Genoa have already caused quite a few upsets this season, taking point off Inter and Napoli in recent weeks.
Gasperini is a former Juventus youth team Coach who trained many of their current stars when they were in the academy.
Isaac Cofie sits out a ban, while Alessandro Gamberini, Luca Antonini, Sime Vrsaljko and Juraj Kucka are injured.
Gilardino leads the attack with Andrea Bertolacci and Giuseppe Sculli.
Genoa: Perin; Burdisso, De Maio, Marchese; Motta, Sturaro, Matuzalem, Bertolacci; Antonelli, Gilardino, Sculli
Juventus: Buffon; Caceres, Bonucci, Chiellini; Lichtsteiner, Vidal, Pirlo, Pogba, Asamoah; Llorente, Osvaldo