Rodrigo Palacio and Mauro Icardi face Maxi Moralez and German Denis in an all-Argentine Inter-Atalanta.
It kicks off at San Siro at 14.00 GMT, click here for a match preview.
The Nerazzurri are looking for a fourth consecutive clean sheet, something the club hasn’t achieved since the Jose Mourinho era of the Treble.
They have climbed back into contention for fourth place and they will be eager to take advantage if Fiorentina slip up away to Napoli this evening.
Juan Jesus sits out the final game in his three-match ban, while Marco Andreolli is on the treatment table.
Palacio partners Icardi with ex-Torino winger Danilo D’Ambrosio joining Jonathan and Hernanes.
Walter Samuel starts from the bench on his 36th birthday.
Atalanta are without Yohan Benalouane, who begins his three-game suspension, while Davide Brivio and Riccardo Cazzola are sidelined.
Denis leads the attack with support from Maxi Moralez and Giacomo Bonaventura, while Luca Cigarini pulls the midfield strings.
This is a Lombardy Derby and also something of a taboo for Inter, who haven’t beaten Atalanta since 2010.
The last five encounters, home and away, saw two Orobici victories and three draws, including the 4-3 win at San Siro last season.
Inter: Handanovic; Campagnaro, Ranocchia, Rolando; Jonathan, Guarin, Cambiasso, Hernanes, D'Ambrosio; Palacio, Icardi
Atalanta: Consigli; Nica, Stendardo, Yepes, Del Grosso; Estigarribia, Cigarini, Carmona, Bonaventura; Maxi Moralez; Denis