It’s a head-to-head between third and fourth, as Napoli host Fiorentina in an early taster of the Coppa Italia Final.
The Serie A tie kicks off at the Stadio San Paolo at 17.30 GMT, click here for a match preview.
Both sides crashed out of the Europa League on Thursday despite strong performances and will meet again in Rome for the Coppa Italia Final in May.
The Viola were eliminated by Juventus thanks to an Andrea Pirlo free kick after Gonzalo Rodriguez saw red.
Napoli wasted numerous chances and were made to pay, as a 2-2 home draw with Porto failed to overturn the 1-0 first leg defeat.
Borja Valero is back after completing his three-match ban, though David Pizarro joins Anderson, Giuseppe Rossi and Ante Rebic on the injury list.
Mario Gomez leads the attack with Juan Cuadrado and the returning Joaquin, while Marko Bakic comes into midfield.
Napoli are still without Christian Maggio after emergency surgery for a collapsed lung and long-term absentees Juan Camilo Zuniga and Rafael.
Gonzalo Higuain is supported by Lorenzo Insigne, Jose Callejon and Marek Hamsik, while Jorginho is available again, as he’s ineligible for the Europa League games.
Anthony Reveillere returns to the right-back role, as versatile Henrique moves to the centre in place of Federico Fernandez.
When these teams met earlier this season, Napoli secured a hugely controversial 2-1 victory in Florence. Cuadrado was sent off for simulation in the final minute when he should’ve received a penalty instead.
It is raining very heavily in Naples this evening and that could affect Fiorentina’s passing play.
Napoli: Reina; Reveillere, Henrique, Albiol, Ghoulam; Inler, Jorginho; Insigne, Hamsik, Callejon; Higuain
Napoli bench: Colombo, Doblas, Britos, Mesto, Fernandez, Behrami, Dzemaili, Bariti, Radosevic, Mertens, Pandev, Duvan
Fiorentina: Neto; Tomovic, Rodriguez, Savic, Pasqual; Bakic, Aquilani, Borja Valero; Cuadrado, Joaquin, Gomez
Fiorentina bench: Rosati, Lupatelli, Diakite, Compper, Mati Fernandez, Ambrosini, Wolski, Matos, Matri, Tomovic, Vargas, Ilicic