Lazio and Milan are two teams on the verge of a nervous breakdown and go head-to-head this evening with Mario Balotelli dropped.
It kicks off at the Stadio Olimpico at 19.45 GMT, click here for a match preview.
The atmosphere in Rome is extremely tense, as the home fans continue their protest against President Claudio Lotito and Clarence Seedorf is beset by rumours he’ll be fired if Milan suffer a heavy defeat tonight.
It would be a shock considering Seedorf only replaced Massimiliano Allegri in January, but the Rossoneri are coming off four consecutive defeats in all competition.
Christian Abbiati is suspended after his red card in the 4-2 loss to Parma, while Ignazio Abate and Stephan El Shaarawy are injured.
Mario Balotelli is not 100 per cent fit or on form, so Giampaolo Pazzini takes his place with Keisuke Honda favoured to Adel Taarabt.
Lazio are without their first choice goalkeeper too, as Federico Marchetti has been suffering from flu symptoms, so Albanian Etrit Berisha starts.
He joins Michael Ciani and Ederson on the treatment table, but Antonio Candreva returns from his ban.
Miroslav Klose is not even fit for the bench, so Brayan Perea starts with teenage sensation Keita Balde Diao.
Lazio: Berisha; Konko, Biava, Novaretti, Radu; Gonzalez, Ledesma, Biglia; Candreva, Keita, Perea
Lazio bench: Guerrieri, Strakosha, Mauri, Felipe Anderson, Pereirinha, Lulic, Kakuta, Onazi, Cana, Cavanda, Postiga
Milan: Amelia; De Sciglio, Rami, Mexes, Constant; De Jong, Essien; Kaka, Poli, Honda; Pazzini
Milan bench: Gabriel, Bonera, Zapata, Zaccardo, Emanuelson, Muntari, Montolivo, Birsa, Saponara, Taarabt, Robinho, Balotelli