Roma give Rafael Toloi his debut in defence as they welcome Torino’s dynamic duo Ciro Immobile and Alessio Cerci.
It kicks off at the Stadio Olimpico at 19.45 GMT, click here for a match preview.
This tie opens up Serie A Week 30, a midweek round that will mainly be played out tomorrow evening.
Roma consolidated second place with a 2-0 win away to Chievo on Saturday, but lost Mehdi Benatia to suspension.
It means a change in the centre-back pairing, as Rafael Toloi is given his Serie A debut alongside Leandro Castan.
The 23-year-old Brazilian only arrived on deadline day in the January transfer window on loan from Sao Paulo and has not played a single minute of football for Roma.
Alessio Romagnoli remains at left-back with Douglas Maicon on the right, while Daniele De Rossi returns from his three-match ban for punching Inter’s Mauro Icardi.
With Kevin Strootman out for the season following knee surgery, Rodrigo Taddei steps on to the bench to make way for De Rossi.
Francesco Totti leads the attack with Gervinho and Mattia Destro, who will be scouted by Italy Coach Cesare Prandelli tonight.
The Azzurri boss isn’t just there to view Destro, as he’ll also keep a World Cup eye on Torino striker Immobile.
He scored a hat-trick in Torino’s 3-1 win over Livorno on Saturday and is now joint Capocannoniere with Carlos Tevez on 16 goals.
Immobile is partnered with Cerci, a former Roma youth product who has been linked with a summer return to his hometown club.
Paulo Vitor Barreto, Migjen Basha, Salvatore Masiello and Marcelo Larrondo are unavailable for Coach Giampiero Ventura.
Before kick-off, Roma will present the 2013 inductees into the Hall of Fame: Giuseppe Giannini, Attilio Ferraris, Sebino Nela and the absent Vincenzo Montella.
Roma: De Sanctis; Maicon, Toloi, Castan, Romagnoli; Pjanic, De Rossi, Nainggolan; Gervinho, Destro, Totti
Torino: Padelli; Bovo, Glik, Moretti; Maksimovic, Kurtic, Vives, El Kaddouri, Darmian; Cerci, Immobile