Napoli need to get back on track, but face a tricky visit to desperate bottom of the table Catania with many changes.
It kicks off at 19.45 GMT, click here for a match preview.
The Partenopei are in dire need of a boost, as over the last week they have gone out of the Europa League and lost at home to Fiorentina, effectively losing sight of second place.
Faouzi Ghoulam was sent off against the Viola on Sunday and therefore suspended for this game.
The injury list was also extended with Dries Mertens, Valon Behrami, Christian Maggio, Juan Camilo Zuniga and Rafael.
Gonzalo Higuain is given a rare rest after five consecutive starts, making way for Duvan Zapata, while Raul Albiol and Gokhan Inler are also benched.
Catania are propping up the standings, but made Juve suffer for a 1-0 result at the Stadio Massimino on Sunday.
Gonzalo Bergessio received a red card in that game and sits out a ban, so the Sicilians have to do without their top scorer.
Lucas Castro is also injured, so Keko and Pablo Barrientos form the attack with Francesco Lodi in midfield.
History doesn’t bode well for Napoli, who have never won any of their 12 visits to Catania, losing six of them and failing to score in eight.
Catania: Andujar; Bellusci, Legrottaglie, Gyomber; Peruzzi, Izco, Lodi, Rinaudo, Monzon; Barrientos, Keko
Napoli: Reina; Henrique, Fernandez, Britos, Reveillere; Jorginho, Dzemaili; Insigne, Hamsik, Callejon; Duvan Zapata