Mario Balotelli, Keisuke Honda, Kaka and Adel Taarabt start as Milan try to break down tough cookies Chievo.
It kicks off at San Siro at 19.45 GMT, click here for the match preview.
The Rossoneri got themselves back on track in the last week, earning a draw at Lazio and a 2-0 victory away to Fiorentina.
However, Clarence Seedorf still needs to improve their performances at San Siro to win over the home fans and this is the ideal opportunity.
Milan have never lost this fixture in Serie A, earning nine wins and two draws against the Flying Donkeys.
Changes are forced in several areas of the team, as Philippe Mexes and Kevin Constant are both suspended.
The injury list includes Riccardo Montolivo, Ignazio Abate, Mattia De Sciglio, Marco Amelia, Stephan El Shaarawy and Andrea Petagna.
Balotelli leads the attack with support from Honda, Taarabt and Kaka, while Cristian Zaccardo and Daniele Bonera step into the back four.
Chievo are fresh from their 3-0 demolition job on Bologna, which allowed them to break away from the drop zone.
They aren’t safe yet and visit San Siro without the suspended Luca Rigoni in midfield, while Matteo Rubin and Roberto Guana are also sidelined.
There is a familiar face up front, as Alberto Paloschi grew up in the Milan academy, scored within a minute of his Serie A debut in this very stadium and is still co-owned by the Rossoneri.
He is partnered by Victor Obinna, the Nigeria international who is preparing for the World Cup, with Perparim Hetemaj in the trequartista role.
Michael Agazzi is in goal and it’s reported he has already agreed a free transfer to Milan for the summer.
Milan: Abbiati; Bonera, Zaccardo, Rami, Emanuelson; De Jong, Muntari; Honda, Kakà, Taarabt; Balotelli
Milan bench: Gabriel, Coppola, Silvestre, Zapata, Essien, Birsa, Poli, Saponara, Robinho, Pazzini
Chievo: Agazzi; Sardo, Dramé, Frey, Dainelli, Bernardini; Radovanovic, Bentivoglio Hetemaj; Obinna, Paloschi
Chievo bench: Puggioni, Squizzi, Do Santos, Canini, Kupisz, Lazarevic, Cesar, Paredes, Guarente, Stojan, Pellissier, Thereau