Lazio and Parma go head-to-head for Europa League places as Antonio Cassano takes on Miroslav Klose.
It kicks off at the Stadio Olimpico at 14.00 UK time (13.00 GMT), click here for a match preview.
There are currently five points separating the two sides as they go into the Stadio Olimpico, but it’ll feel like an away fixture for Lazio as the fans continue their anti-Claudio Lotito protest by abandoning the Curva Nord.
Klose returns to the side after specialist consultation on his back injury, while Federico Marchetti also makes his comeback.
Cristian Ledesma is suspended with Lucas Biglia, Andre Dias, Bruno Pereirinha and Ederson injured, so Edy Reja has to reshuffle his midfield with Lorik Cana moved up.
Parma saw their club record 17-round unbeaten run come to an end on Wednesday night against Juventus.
Amauri was sent off in that game and begins a three-match ban, while Gabriel Paletta, Walter Gargano and Nicola Pozzi are injured.
Cassano leads the attack with Jonthan Biabiany and Ezequiel Schelotto in a 4-3-3 formation.
Lazio: Marchetti; Konko, Biava, Novaretti, Radu; Onazi, Cana; Candreva, Mauri, Lulic; Klose
Lazio bench: Berisha, Strakosha, Ciani, Anderson, Kakuta, Pereia, Cavanda, Postiga, Minala, Keita
Parma: Mirante; Cassani, Lucarelli, Felipe, Gobbi; Acquah, Marchionni, Parolo; Biabiany, Cassano, Schelotto
Parma bench: Pavarini, Bajza, Molinaro, Galloppa, Cerri, Palladino, Obi, Jankovic, Munari, Mauri, Rossini, Sall