Chievo and Verona play the Derby della Scala today, followed by Inter-Bologna, while Monday sees Juventus-Livorno and Genoa-Milan.
It all kicks off at 17.00 UK time (16.00 GMT) with the Verona Derby between Chievo and Hellas, then at 19.45 UK time stuttering Inter host relegation battlers Bologna.
The early Sunday kick-off is an intriguing Lazio-Sampdoria between two very unpredictable sides.
In the afternoon Roma try to put more pressure on leaders Juventus by visiting Cagliari, while Fiorentina take on Udinese and Atalanta try to extend their club record six straight wins with Sassuolo.
Catania’s hopes of survival are hanging by a thread and Torino could cut it tomorrow.
The Sunday evening match is sure to be fiery, as Antonio Cassano’s Parma take on a revitalised Napoli.
Juve welcome Livorno on Monday at 18.00 UK time (17.00 GMT), followed by a fascinating Genoa-Milan at 20.00 UK time.