Atalanta are chasing a seventh consecutive victory against Sassuolo and can also hunt down Inter for Europe.
It kicks off at 14.00 UK time (13.00 GMT), click here for a match preview.
“What we have achieved is not something anyone can do,” said Stefano Colantuono in his Press conference.
“Usually only big clubs win six in a row thanks to the quality of their squads and the winning mentality.
“Instead, even when it seemed to be an off day, we managed to find the moment that turned the game around.”
A run of six consecutive victories is already a Serie A record for Atalanta, but a seventh is almost expected against struggling Sassuolo.
“I consider Sassuolo to be a very good side, so we must be careful and face them with the same attitude as if we were playing Inter or Juventus,” warned the Coach.
“We are in good shape, both physically and psychologically. Europe? We’ve just got to focus on ourselves now.”
The Orobici are on 46 points, just one off sixth-placed Parma and four shy of Inter in fifth.
Guglielmo Stendardo is suspended, while Riccardo Cazzola, Maxi Moralez and Davide Brivio are sidelined.
Atalanta squad for Sassuolo: Baselli, Bellini, Benalouane, Betancourt, Bonaventura, Brienza, Carmona, Cigarini, Consigli, De Luca, Del Grosso, Denis, Estigarribia, Frezzolini, Giorgi, Kone, Livaja, Lucchini, Migliaccio, Nica, Raimondi, Scaloni, Sportiello, Yepes