Lazio must beat Sampdoria to continue their European ambitions, but lose Miroslav Klose, so Helder Postiga starts.
The Stadio Olimpico hosts this fixture at 11.30 UK time (10.30 GMT), click here for a match preview.
Edy Reja remains confident his men can qualify for the Europa League, but time is running out and competition is fierce.
He has to do without Federico Marchetti, Andre Dias, Diego Novaretti, Emerson and the suspended Cristian Ledesma.
Hitman Klose was due to play, but was ruled out at the last minute by muscular problems, so Helder Postiga gets his first Serie A start.
Lucas Biglia returns to bolster the midfield, while Antonio Candreva and exciting teenage talent Keita Balde Diao support Postiga.
Etrit Berisha takes the gloves, as Marchetti is out with a muscular problem.
Sampdoria are missing two key figures in Rome, as captain Daniele Gastaldello is injured and Coach Sinisa Mihajlovic begins his two-game touchline ban.
It’s a heavy blow for Mihajlovic, who spent many years at Lazio as a player and then as assistant manager.
He’s replaced on the bench by his assistant Nenad Sakic.
Manolo Gabbiadini, Eder and Roberto Soriano fan out behind Maxi Lopez, while Vasco Regini returns from suspension to become a makeshift centre-back.
Sampdoria tweeted a picture of their team bus this morning, noting it was vandalised overnight with graffiti painted on the sides.
Lazio: Berisha; Konko, Biava, Cana, Radu; Onazi, Biglia, Lulic; Candreva, Postiga, Keita
Lazio bench: Strakosha, Guerrieri, Ciani, Pereirinha, Cavanda, Serpieri, Mauri, Minala, Felipe Anderson, Perea, Kakuta
Sampdoria: Da Costa; De Silvestri, Mustafi, Regini, Berardi; Palombo, Krsticic; Gabbiadini, Eder, Soriano; Maxi Lopez
Sampdoria bench: Fiorillo, Costa, Fornasier, Rodriguez, Salamon, Bjarnason, Obiang, Renan, Sestu, Wszolek, Okaka, Sansone