Roma can temporarily close the gap to five points, but first need to end their Cagliari taboo, as they haven’t won here for 19 years.
It kicks off at the Stadio Sant’Elia at 14.00 UK time (13.00 GMT), click here for a match preview.
The Giallorossi are on a strong run of results and have moved to within eight points of leaders Juventus, so the Scudetto race isn’t over yet.
At the same time, they also need to put second place and automatic Champions League qualification under lock and key with Napoli bearing down on them.
Kevin Strootman and Federico Balzaretti are injured, while Francesco Totti is rested, but Douglas Maicon shook off a knock to start.
Mattia Destro is therefore supported by Gervinho and Alessandro Florenzi, while it is an emotional reunion for ex-Cagliari star Radja Nainggolan.
The Sardinians have not yet secured their Serie A safety and once again the Stadio Sant’Elia capacity is only 5,000 due to reconstruction work.
Adryan, Matias Vecino and the suspended Luca Rossettini are unavailable for Coach Diego Lopez.
Roma haven’t won away to Cagliari since 1995, as last season’s fixture wasn’t played at all.
The 3-0 result was handed to the Giallorossi after Massimo Cellino invited supporters to attend the game, even though it was to be played behind closed doors. The authorities therefore cancelled the match amid security fears.
Cagliari: Avramov; Pisano, Oikonomou, Astori, Avelar; Ekdal, Dessena, Conti; Cossu; Pinilla, Nene
Roma: De Sanctis; Maicon, Benatia, Castan, Romagnoli; Nainggolan, De Rossi, Pjanic; Florenzi, Destro, Gervinho
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!