Juventus take on desperate Livorno in the 18.00 UK time kick-off after Roma closed the gap to five points.
It starts in Turin at 18.00 UK time (17.00 GMT), click here for a match preview.
The Bianconeri are caught between needing to rotate the squad ahead of Thursday’s Europa League quarter-final with Lyon and defending their Serie A leadership.
They were beaten 2-0 by Napoli last week and Roma’s successful run has closed the gap at the top of the table to only five points.
Andrea Barzagli is still out injured with Arturo Vidal suspended, while Carlos Tevez starts despite a muscular problem he suffered in Lyon.
He partners Fernando Llorente, while Giorgio Chiellini starts against his hometown club.
Livorno are in the bottom three, but boosted their confidence last week by fighting back from 2-0 down to hold Inter 2-2.
Andrea Luci, Emerson and Ibrahima Mbaye are all injured, while top scorer Paulinho is not risked from the start.
That’s because the Brazilian is one yellow card away from suspension and Livorno cannot afford to miss him in next week’s relegation dogfight with Chievo.
Instead, Innocent Emeghara and his lightning pace starts with Luca Siligardi, while Ishak Belfodil is on the bench.
This fixture has been played 16 times in Serie A with 14 home victories, one draw (2-2 on December 5 1948) and one Livorno win (3-2 on January 11 1942). In those meetings Juve scored 49 goals and conceded 16.
Juventus: Buffon; Caceres, Bonucci, Chiellini; Lichtsteiner, Pogba, Pirlo, Marchisio, Asamoah; Tevez, Llorente
Juventus bench: Storari, Rubinho, Isla, Ogbonna, Peluso, Padoin, Giovinco, Vucinic, Osvaldo, Quagliarella
Livorno: Bardi; Ceccherini, Valentini, Coda, Castellini; Benassi, Biagianti, Duncan, Mesbah; Emeghara, Siligardi
Livorno bench: Tiritiello, Bartolini, Paulinho, Gemiti, Aldegani, Greco, Mosquera, Anania, Belfodil, Borja, Piccini