Sassuolo host Cagliari with new Coach Ivo Pulga making his debut in a relegation six-pointer.
It kicks off at the Mapei Stadium at 17.00 UK time (16.00 GMT), click here for a match preview.
Both teams are in difficult positions, as Sassuolo are in penultimate place after last week’s shock 2-0 victory away to Atalanta.
Cagliari sacked Coach Diego Lopez last weekend and brought back his former assistant manager Pulga, who had been fired in February.
Sassuolo have Paolo Cannavaro suspended in defence, joining absentees Alexe, Emanuele Terranova, Francesco Acerbi, Matteo Brighi, Luca Marrone and Paolo Bianco.
Simone Zaza and Domenico Berardi lead in attack after their call-up for tests with Cesare Prandelli’s Italy side.
The Sardinians must do without Adryan, Nene, Matias Vecino, Mauricio Pinilla and Albin Ekdal, leaving very few options in attack.
Marco Sau, Victor Ibarbo and Agim Ibraimi therefore start up front.
There were reports Daniele Conti and Andrea Cossu would be dropped for criticising President Massimo Cellino, but captain Conti is in the starting XI.
Sassuolo: Pegolo; Gazzola, Antei, Ariaudo, Longhi; Biondini, Magnanelli, Missiroli; Berardi, Zaza, Sansone
Sassuolo bench: Pomini, Polito; Pucino, Mendes, Rosi, Ziegler, Chibsah, Masucci, Farias, Sanabria, Floccari, Floro Flores
Cagliari: Avramov; Pisano, Rossettini, Astori, Murru; Dessena, Conti, Eriksson; Ibarbo, Sau, Ibraimi
Cagliari bench: Silvestri, Perico, Avelar, Del Fabro, Cossu, Tabanelli, Loi