Leandro Castan is confident Roma can get the better of Atalanta even without Mattia Destro and Mehdi Benatia.
It kicks off at 19.45 UK time (18.45 GMT), click here for the official line-ups.
“We must try to win, do our work and see what happens ahead of us,” defender Castan told the media.
“We know it isn’t easy, as the title race doesn’t just depend on us, but we’ll see if we can get past Atalanta.
“The defence is entirely made up of Brazilians tonight, which is different for us. We all speak the same language and can therefore communicate better.
“My work doesn’t change with Rafael Toloi next to me, but he needs to show his worth now the same way Benatia did. We will help him to achieve that.”