Former friendships are back in the frame today with Napoli-Lazio, Verona-Fiorentina and above all Sampdoria-Inter.
Click here for match previews of every single Serie A Week 33 fixture, plus reports from Saturday’s Sassuolo-Cagliari and Roma-Atalanta.
It all begins with the Emilia-Romagna Derby between Bologna and Parma at 11.30 UK time (10.30 GMT), as the local rivals fight for very different targets.
This afternoon Napoli host Lazio with their old Coach Edy Reja amid an injury crisis, while Luca Toni and Romulo want to prove a point in Verona-Fiorentina.
There are several grudge matches in Sampdoria-Inter, including Sinisa Mihajlovic in the stands against his former club and Maxi Lopez against ex-friend Mauro Icardi.
Livorno-Chievo is a decisive relegation six-pointer, while Torino-Genoa provides a mid-table tussle.
This evening Milan take on Catania with Coach Maurizio Pellegrino making his Serie A debut.
The round concludes on Monday night when leaders Juventus visit Udinese.