The Emilia-Romagna Derby has a lot riding on it, as Bologna fight to avoid relegation and Parma push for Europe.
It kicks off at 11.30 UK time (10.30 GMT), click here for a match preview.
Bologna host this clash at the Stadio Dall’Ara and are desperate for points, as they sit just two clear of the drop zone.
The Rossoblu had failed to score from open play for eight games, but netted twice in their surprise 2-2 draw with Inter at San Siro last week.
Rene Krhin is out of action along with Jose Crespo and Francesco Della Rocca, so Panagiotis Kone and Lazaros Christodoulopoulos support Jonathan Cristaldo.
Parma are fresh from a shock victory over Napoli that put them into joint fifth place alongside Inter.
Antonio Cassano, Nicola Pozzi and Jherson Vergara are unavailable along with the suspended Marco Parolo.
However, Amauri, Alessandro Lucarelli and Walter Gargano are back in the squad, though Raffaele Palladino is picked to start.
Bologna have won just one of their last seven encounters with neighbours Parma and last season the Ducali emerged 2-1 victors.
Bologna: Curci; Antonsson, Natali, Cherubin; Garics, Pazienza, Friberg, Christodoulopoulos, Morleo; Kone; Cristaldo
Bologna bench: Stojanovic, Sorensen, Bianchi, Moscardelli, Acquafresca, Laxalt, Perez, Barreto da Silva, Mantovani, Cech, Paponi
Parma: Mirante; Cassani, Lucarelli, Paletta, Molinaro; Acquah, Marchionni, Gargano; Biabiany, Palladino, Schelotto
Parma bench: Pavarini, Bajza, Galloppa, Cerri, Amauri, Gobbi, Felipe, Obi, Jankovic, Munari, Mauri, Rossini