Lazio take on Torino in a potential play-off for Europa League places, but both sides have problems going in.
It kicks off at the Stadio Olimpico in Rome at 14.00 UK time (13.00 GMT), click here for a match preview.
The clubs are locked together in joint seventh place with Milan, but only the top six will go into Europe.
Edy Reja’s Lazio are without Miroslav Klose, Federico Marchetti, Abdoulay Konko, Andre Dias, Alvaro Gonzalez and Ederson.
Lucas Biglia returns from suspension, but is replaced on the naughty step by Lorik Cana.
Keita Balde Diao has shaken off an injury to start in attack with Antonio Candreva and Stefano Mauri in a new 3-4-3 formation.
Torino have their own issues to deal with, though are in great shape after three consecutive victories, including last week’s 2-1 over Genoa when they had been 1-0 down until stoppages.
Alessio Cerci is their second top scorer, but he sits out a ban today, joining the injured Giovanni Pasquale, Marcelo Larrondo, Migjen Basha, Alexander Farnerud, Salvatore Masiello and Guillermo Rodriguez.
This puts even more pressure on current Serie A Capocannoniere Ciro Immobile, who leads the way with support from Riccardo Meggiorini.
Lazio: Berisha; Biava, Novaretti, Radu; Cavanda, Biglia, Ledesma, Lulic; Candreva, Mauri, Keita
Lazio bench: Strakosha, Guerrieri, Ciani, Pereirinha, Crecco, Onazi, Minala, Felipe Anderson, Kakuta, Postiga, Perea
Torino: Padelli; Bovo, Glik, Moretti; Maksimovic, Kurtic, Vives, El Kaddouri, Darmian; Immobile, Meggiorini
Torino bench: Berni, Barreca, Vesovic, Gazzi, Tachtsidis, Barreto, Gyasi