Roma and Milan field two attack-minded line-ups as they go head-to-head at the Olimpico tonight.
The Serie A encounter kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
The Giallorossi have already secured second place and qualification into the Champions League group phase, while they still have a slim chance of catching Serie A leaders Juventus.
Mattia Destro continues his four-match ban and misses out along with the injured Mehdi Benatia, Kevin Strootman and Federico Balzaretti.
Francesco Totti and Gervinho lead the way with Adem Ljajic picked ahead of Alessandro Florenzi in the trident.
Rafael Toloi again takes over from Benatia in an all-Brazilian back four, as Roma are looking for a ninth consecutive victory.
Milan are on fine form too, as for the first time since November 2011 they have won five Serie A games on the trot.
Clarence Seedorf is settling into his role as Coach, even though rumours persist of problems with the club hierarchy that could see him walk away in the summer.
Keisuke Honda returns to the starting XI after his injury and supports Mario Balotelli with Ricky Kaka and Adel Taarabt.
Nigel De Jong is a big miss for the Rossoneri in midfield due to a ban, so Sulley Muntari steps in with Riccardo Montolivo.
It’s a special game for Philippe Mexes, who played for Roma from 2004 to 2011 before moving to Milan on a Bosman transfer.
Milan’s last victory at the Stadio Olimpico was 3-2 in October 2011.
Roma: De Sanctis; Maicon, Toloi, Castan, Dodò; Pjanic, De Rossi, Nainggolan; Gervinho, Totti, Ljajic
Milan: Abbiati; Bonera, Rami, Mexes, Constant; Montolivo, Muntari; Honda, Kaka, Taarabt; Balotelli