Lazio and Livorno are forced to reshuffle in a grudge match that can prove crucial for European and relegation races.
It kicks off at the Stadio Armando Picchi at 14.00 UK time (13.00 GMT), click here for a match preview.
There is plenty at stake here and not just because it’s a bitter grudge match between fans with a fierce rivalry.
The hosts are desperate to escape the relegation zone, while the Biancocelesti need points to have any hope of qualifying for Europe.
Livorno welcome back Coach Davide Nicola, who had been fired in January and recalled last week following Mimmo Di Carlo’s dismissal.
He is forced to do without Innocent Emeghara, Ibrahima Mbaye, Federico Ceccherini and Andrea Luci.
Ishak Belfodil is still benched in favour of Mesbah in a more advanced role with Paulinho and Luca Siligardi.
Lazio have Stefan Radu and Diego Novaretti suspended, while Miroslav Klose, Federico Marchetti, Andre Dias, Abdoulay Konko, Helder Postiga and Ederson fill the treatment table.
Giuseppe Biava is only fit for the bench, so Bruno Pereirinha and Senad Lulic become full-backs with Michael Ciani in the centre of defence.
Stefano Mauri acts as the link between midfield and attack with Antonio Candreva and Keita Balde Diao.
The last time this fixture ended in a home win was 2005-06, as Lazio picked up a draw and two victories here.
Livorno: Bardi; Valentini, Rinaudo, Emerson, Castellini; Duncan, Biagianti, Greco; Paulinho, Siligardi, Mesbah
Lazio: Berisha; Pereirinha, Ciani, Cana, Lulic; Onazi, Ledesma, Biglia; Mauri; Candreva, Keita
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!