Milan must win away to Atalanta in the Derby della Lombardia to keep Europa League dreams alive.
It kicks off in Bergamo at 11.30 UK time (10.30 GMT), click here for a match preview.
The Rossoneri have won six of the last seven rounds, including a 1-0 result over arch rivals Inter, to get back into the race for Europe.
Clarence Seedorf remains in the balance after yet more insulting comments from President Silvio Berlusconi, so even qualifying for the continent might not save the Coach.
He debuted a new 4-3-1-2 system in the Derby and sticks with it in Bergamo, using Keisuke Honda behind Mario Balotelli and Ricky Kaka.
Mattia De Sciglio and Kevin Constant are the full-backs, but Marco Amelia starts in goal to replace the suspended Christian Abbiati.
Valter Birsa and Riccardo Saponara are now the only absentees, as Stephan El Shaarawy is on the bench hoping for his first appearance of 2014.
Atalanta have already secured mid-table comfort some time ago, but want to make a good impression against local rivals in their final game of the season at the Stadio Azzurri d’Italia.
German Denis and Maxi Moralez lead the way with Giacomo Bonaventura and Luca Cigarini pulling the midfield strings.
Marcelo Estigarribia is suspended, while there is an emergency in defence due to injuries for Mario Yepes, Guglielmo Stendardo, Stefano Lucchini and Riccardo Cazzola.
Inter-owned striker Marko Livaja has been frozen out following his online insults aimed at fans.
Milan have a good record in Bergamo, as they are unbeaten here since 2008.
Atalanta: Consigli; Raimondi, Benalouane, Bellini, Brivio; Baselli, Cigarini, Carmona; Moralez, Bonaventura; Denis
Atalanta bench: Sportiello, Frezzolini, Caldara, Scaloni, Del Grosso, Migliaccio, Nica, Giorgi, Kone, Bentancourt, Brienza, De Luca
Milan: Abbiati; De Sciglio, Rami, Mexes, Constant; Montolivo, De Jong, Muntari; Honda; Kaka, Balotelli
Milan bench: Coppola, Gabriel, Abate, Bonera, Zapata, Emanuelson, Essien, Taarabt, Poli, El Shaarawy, Robinho, Pazzini