Eusebio Di Francesco’s Sassuolo already beat Milan once this season and want to repeat the trick at San Siro.
It kicks off this evening at 19.45 UK time (18.45 GMT), click here for a match preview.
The Neroverdi earned a shock 4-3 win in January, which proved to be the final straw for Massimiliano Allegri’s tenure, ushering in the Clarence Seedorf era.
“We all really want to do well, starting from our patron, who doesn’t want to make a bad impression,” smiled Di Francesco.
Sassuolo owner Lorenzo Squinzi is a self-confessed Rossoneri supporter and can let loose now that the club has secured safety in its first ever Serie A campaign.
“It has been a special week in which we thought more about celebrating than anything else, which is only normal.
“Milan’s results haven’t been that bad and I don’t believe they are a team in crisis.
“I can confirm Alberto Pomini will start in goal, but I don’t predict any massive changes in the rest of the line-up.
“Sassuolo deserved all the praise we received this week and I am glad my work was appreciated.”
They are without Reto Ziegler, Sergio Floccari, Francesco Acerbi, Paolo Bianco, Thomas Manfredini and Marius Alexe.
Sassuolo squad for Milan: Pegolo, Polito, Pomini, Antei, Ariaudo, Cannavaro, Gazzola, Longhi, Mendes, Pucino, Rosi, Terranova, Biondini, Brighi, Chibsah, Magnanelli, Marrone, Missiroli, Berardi, Floro Flores, Masucci, Sanabria, Sansone, Zaza