Spain make changes in their must-win showdown with Chile, as the reigning World Cup holders risk crashing out.
It kicks off at 20.00 UK time (19.00 GMT) at the legendary Maracana in Rio de Janeiro.
Vicente Del Bosque said he could be forced to switch things around after a shock 5-1 defeat at the hands of the Netherlands.
They need a victory, as Chile won their opener by beating Australia 2-1.
Iker Casillas was guilty of a howler against Holland, but with Manchester United’s David De Gea suffering from a muscular problem, the only alternative is Napoli’s Pepe Reina.
Despite a poor performance in the opener, Diego Costa retains his place in attack supported by David Silva.
There are changes, as Bayern Munich’s Javi Martinez comes into central defence for Gerard Pique and Pedro replaces Xavi.
Chile again start Arturo Vidal, as the Juventus midfielder is on the road to full fitness after knee surgery last month.
The key man in attack is ex-Udinese talent Alexis Sanchez, who will be taking on many of his Barcelona teammates this evening.
Other familiar faces to Serie A include Juventus full-back Mauricio Isla and Napoli-owned Edu Vargas.
Spain: Casillas; Azpilicueta, Javi Martinez, Ramos, Alba; Xabi Alonso, Busquets; Iniesta, Pedro, Silva; Diego Costa
Chile: Bravo; Isla, Medel, Jara, Silva, Mena; Diaz, Vidal, Aranguiz; Alexis Sanchez, Vargas