Lazio were swept aside 3-1 by Hannover in Germany on Marco Parolo and Stefan De Vrij full debuts.
Stefano Pioli threw the two new signings in from the start at the HDI-Arena against a team ready to start the Bundesliga next weekend.
The hosts broke through after 21 minutes when Marcelo rose above the crowd to nod in a corner kick.
Leonardo Bittencourt pounced on a Michael Ciani error, but lobbed off target with only Federico Marchetti to beat.
Antonio Candreva wasn’t so fortunate, as his howler did lead to a goal, Bittencourt rolling across for the unmarked Lars Stindl.
Leon Andreasen’s header skimmed the woodwork and Joselu failed to make the most of a Marchetti howler, but the goalkeeper did better when parrying Bittencourt’s curler.
Lazio’s first chance of the game was after 55 minutes, as the goalkeeper managed to block Filip Djordjevic’s audacious backheel flick on the line.
Keita Balde Diao came off the bench and was brought down by Christian Schulz for a penalty, which Cristian Ledesma converted.
However, Hannover restored their two-goal cushion with Stindl getting on the end of a long ball.
Keita continued to fight hard, his effort deflected wide, and Tounkara’s chip was off target.
Hannover 3-1 Lazio
Scorers: Marcelo 21 (H), Stindl 38, 74 (H), Ledesma pen 66 (L)
Hannover: Zieler; Sakai, Schulz, Marcelo, Pander; Andreasen, Schmiedebach; Bittencourt, Stindl, Prib; Joselu
Lazio: Marchetti; Basta (Cavanda 36), De Vrij (Felipe Anderson 59), Ciani, Braafheid (Radu 75); Pereirinha (Keita 46), Gonzalez (Ledesma 59), Parolo (Novaretti 59); Candreva (Cataldi 59), Djordjevic (Tounkara 59), Lulic (Mauri 59)