Sassuolo crushed Cittadella, but Chievo suffered a shock Coppa Italia exit at the hands of Pescara.
The Third Round began this evening with two fixtures and continues through to Monday night.
The Serie A clubs enter the fray from this stage and there have already been surprises, as Chievo crashed out with a 1-0 defeat to Pescara.
Sassuolo made short work of Cittadella, winning their fixture 4-1 with Nicola Sansone bagging a brace.
These results mean Pescara will take on Sassuolo in the Fourth Round in December.
Pescara 1-0 Chievo
Scorers: Maniero 38 (P)
Sassuolo 4-1 Cittadella
Scorers: Zaza 12 (S), Coralli 33 (C), Sansone 53, 83 (S), Floro Flores 92 (S)
Tickets for the Champions League final between Juventus and Real Madrid are still on sale with reseller Viagogo - Click to find out more