Sassuolo crushed Cittadella, but Chievo suffered a shock Coppa Italia exit at the hands of Pescara.
The Third Round began this evening with two fixtures and continues through to Monday night.
The Serie A clubs enter the fray from this stage and there have already been surprises, as Chievo crashed out with a 1-0 defeat to Pescara.
Sassuolo made short work of Cittadella, winning their fixture 4-1 with Nicola Sansone bagging a brace.
These results mean Pescara will take on Sassuolo in the Fourth Round in December.
Pescara 1-0 Chievo
Scorers: Maniero 38 (P)
Sassuolo 4-1 Cittadella
Scorers: Zaza 12 (S), Coralli 33 (C), Sansone 53, 83 (S), Floro Flores 92 (S)