Napoli have Jonathan De Guzman and Michu in their squad to face Genoa, but Goran Pandev is dropped.
Their Serie A opener kicks off on Sunday at 19.45 UK time (18.45 GMT), click here for a match preview.
Rafa Benitez needs to raise their spirits after the Champions League play-off defeat to Athletic Bilbao.
New signing De Guzman could be given his debut for the Partenopei, as he has made the trip along with fellow ex-Swansea man Michu.
However, Pandev and Blerim Dzemaili are left behind, fuelling reports they will be sold before Monday’s transfer deadline.
Faouzi Ghoulam is out of action for at least three weeks after fracturing his arm.
Napoli squad for Genoa: Rafael, Andujar, Colombo, Maggio, Mesto, Henrique, Albiol, Koulibaly, Britos, Zuniga, Inler, Gargano, Jorginho, De Guzman, Callejon, Insigne, Mertens, Hamsik, Michu, Higuain, Duvan Zapata