Inter give 17-year-old hitman Federico Bonazzoli a surprise start with Mateo Kovacic against Saint-Etienne.
The Europa League tie kicks off at 18.00 GMT and follows on from their 0-0 draw at San Siro, a game with more than a few risks for the Nerazzurri.
Walter Mazzarri remains at risk after a shock 2-0 defeat to Parma at the weekend in Serie A, though they are top of their Europa League group.
Inter give 17-year-old hitman Federico Bonazzoli a surprise start with Mateo Kovacic against Saint-Etienne.
The Europa League tie kicks off at 18.00 GMT and follows on from their 0-0 draw at San Siro, a game with more than a few risks for the Nerazzurri.
Walter Mazzarri remains at risk after a shock 2-0 defeat to Parma at the weekend in Serie A, though they are top of their Europa League group.
An injury crisis has ruled out Hernanes, Danilo D’Ambrosio, Jonathan, Yann M’Vila, Yuto Nagatomo and Hugo Campagnaro, while Fredy Guarin failed a fitness test against his old club.
Daniel Osvaldo is only fit enough for a spot on the bench.
Mauro Icardi is rested, giving 17-year-old Bonazzoli his first start for the club, supported by 21-year-old Croatian international Kovacic and Rodrigo Palacio.
Joel Obi steps into midfield again to plug the gaps.
Inter have not conceded a European goal in 474 minutes of football, so are very close to their club record of 557 minutes set in the 1990-91 UEFA Cup.
Saint-Etienne’s history makes it more than likely the Nerazzurri will break that record, as so far in Group F they have played three 0-0 draws.
However, if the performance at San Siro was anything to go by, the French side will have its fair share of scoring opportunities.
Saint-Etienne: Ruffier; Perrin, Bayal Sall, Pogba; Theophile-Catherine, Lemoine, Clement, Tabanou; Hamouma, Mevlut Erdinc, Gradel
Saint-Etienne bench: Moulin, Brison, Baysse, Diomande, Mollo, Van Wolfswinkel, Monnet-Paquet
Inter: Carrizo; Andreolli, Vidic, Juan Jesus; Mbaye, Kuzmanovic, Medel, Kovacic, Dodò; Bonazzoli, Palacio
Inter bench: Handanovic, Ranocchia, Donkor, Obi, Palazzi, Osvaldo, Icardi