Napoli need a victory against Young Boys after their shock defeat in Switzerland, but Rafa Benitez rotates again.
It kicks off at 20.05 GMT at the Stadio San Paolo for the Europa League.
The Partenopei were caught at the top of Group I by Young Boys and Sparta Prague thanks to a surprise 2-0 defeat in Berne.
Napoli need a victory against Young Boys after their shock defeat in Switzerland, but Rafa Benitez rotates again.
It kicks off at 20.05 GMT at the Stadio San Paolo for the Europa League.
The Partenopei were caught at the top of Group I by Young Boys and Sparta Prague thanks to a surprise 2-0 defeat in Berne.
That result was followed by a violent protest from some ultras, who hurled objects and abuse at the team bus.
They have since picked up the pace considerably in Serie A and beat Roma 2-0 at the weekend, but need to improve their Europea League form fast.
With three teams locked together on six points and only two going through to the next round, every result is decisive.
Lorenzo Insigne and Dries Mertens have tended to interchange, but they start together with Jonathan de Guzman supporting Duvan Zapata.
There are also big changes in the back four, including Paulo Henrique in the centre and the return of Giandomenico Mesto.
Napoli: Rafael; Mesto, Henrique, Koulibaly, Britos; Gargano, Inler; Insigne, De Guzman, Mertens; Zapata
Napoli bench: Andujar, Maggio, Ghoulam, Albiol, Jorginho, Callejon, Higuain
Young Boys: Mvogo; Hadergjonaj, Von Bergen, Vilotic, Rochat; Sanogo Junior; Steffen, Gajic, Bertone, Nuzzolo; Hoarau
Young Boys bench: Wolfli, Lecjaks, Sutter, Nikci, Afum, Zarate, Kubo