Napoli need a victory against whipping boys Slovan Bratislava to be sure of top spot in their Europa League group.
It kicks off at 20.05 GMT at the Stadio San Paolo.
The Partenopei are in dire need of a morale booster after a series of disappointing home results, including 3-3 draws with both Palermo and Cagliari, plus fighting back from 2-0 down to hold Empoli 2-2 at the weekend.
Lorenzo Insigne, Michu and Juan Camilo Zuniga are still long-term absentees, while Rafa Benitez rotates his squad to keep more focus on Serie A.
Napoli need a victory against whipping boys Slovan Bratislava to be sure of top spot in their Europa League group.
It kicks off at 20.05 GMT at the Stadio San Paolo.
The Partenopei are in dire need of a morale booster after a series of disappointing home results, including 3-3 draws with both Palermo and Cagliari, plus fighting back from 2-0 down to hold Empoli 2-2 at the weekend.
Lorenzo Insigne, Michu and Juan Camilo Zuniga are still long-term absentees, while Rafa Benitez rotates his squad to keep more focus on Serie A.
Duvan Zapata leads the line in place of Gonzalo Higuain, supported by Jonathan de Guzman, Dries Mertens and Marek Hamsik.
It is a special game for Hamsik, as he grew up in the Slovan Bratislava youth academy and began his professional career with the Slovak club.
Slovan are the whipping boys of their group and cannot qualify, but warned they “do not want to end the Europa League on zero points.”
Napoli: Andujar; Maggio, Koulibaly, Britos, Ghoulam; Inler, Gargano; Mertens, Hamsik, Callejon; Duvan Zapata
Napoli bench: Rafael, Mesto, Jorginho, Higuain, Henrique, David Lopez, De Guzman
Slovan Bratislava: Pernis; Cikos, Jablonsky, Gorosito, Kolcak; Hudak, Zofcak, Milinkovic; Kubik, Stefanik; Peltier
Slovan bench: Polacek, Siplak, Vrablec, Gasparovic, Fort, Halenar, Duris