Napoli can feel thoroughly confident after a 4-0 first leg victory over Trabzonspor and threaten another hammering.
The second leg kicks off at the Stadio San Paolo at 20.05 GMT.
Rafa Benitez can afford to rest numerous top stars with a 4-0 away win under his belt, especially as the Partenopei are unbeaten in nine European home ties – including seven victories.
Lorenzo Insigne, Juan Camilo Zuniga and Michu are still long-term absentees.
Napoli can feel thoroughly confident after a 4-0 first leg victory over Trabzonspor and threaten another hammering.
The second leg kicks off at the Stadio San Paolo at 20.05 GMT.
Rafa Benitez can afford to rest numerous top stars with a 4-0 away win under his belt, especially as the Partenopei are unbeaten in nine European home ties – including seven victories.
Lorenzo Insigne, Juan Camilo Zuniga and Michu are still long-term absentees.
Despite the situation, Gonzalo Higuain, Jose Callejon and Jonathan de Guzman are still started.
Confirmation goalkeeper Rafael has fallen behind Mariano Andujar in the pecking order, as the Brazilian is now put on Europa League duty.
Trabzonspor are without Essaid Belkalem, Majeed Waris and Mustapha Yatabare, while Jose Bosingwa and Yusuf Erdogan are carrying knocks.
Napoli: Rafael; Mesto, Henrique, Britos, Ghoulam; Jorginho, Inler; Callejon, De Guzman, Mertens; Higuain
Napoli bench: Andujar, Koulibaly, Hamsik, David Lopez, Gargano, Gabbiadini, Duvan Zapata
Trabzonspor: Hakan Arikan; Salih Dursun, Bosingwa, Aykut Demir, Ishak Dogan; Mehmet Ekici, Fatih Atik, Medjani; Ozer Hurmaci, Oscar Cardozo, Erkan Zengin
Trabzonspor bench: Ibrahim Demir, Zeki Yavru, Musa Nizam, Soner Aydogu, Sefa Yilmaz, Constant