Samuel Eto’o, Eder and Luis Muriel form a new Sampdoria trident as Gianfranco Zola tries to keep Cagliari afloat.
It kicks off at Marassi at 17.00 GMT, click here for a match preview.
Sinisa Mihajlovic got the Blucerchiati back on track last week with a 2-1 victory away to Atalanta.
He is still without the injured Ezequiel Munoz and Rizzo, but Eder returns to the side and completes a new trident with Eto’o and Muriel, dropping Stefano Okaka to the bench.
Samuel Eto’o, Eder and Luis Muriel form a new Sampdoria trident as Gianfranco Zola tries to keep Cagliari afloat.
It kicks off at Marassi at 17.00 GMT, click here for a match preview.
Sinisa Mihajlovic got the Blucerchiati back on track last week with a 2-1 victory away to Atalanta.
He is still without the injured Ezequiel Munoz and Rizzo, but Eder returns to the side and completes a new trident with Eto’o and Muriel, dropping Stefano Okaka to the bench.
Djamel Mesbah is a late addition to the absentee list due to a muscular problem.
Cagliari have just one point from five rounds and risk slipping behind Cesena into penultimate place.
Signs appeared outside the training ground this week urging the club to bring back Zdenek Zeman, so the pressure on Coach Zola is immense.
To make matters worse, Daniele Conti and Joao Pedro are both suspended, joining Albin Ekdal, Godfred Donsah and Antonio Balzano on the treatment table.
Zola completely revamps his attack with Diego Farias, Samuele Longo and Paul-Jose M’Poku, moving Andrea Cossu into a deeper role.
Sampdoria: Viviano; De Silvestri, Silvestre, Romagnoli, Regini; Acquah, Palombo, Obiang; Muriel, Eto’o, Eder
Sampdoria bench: Romero, Frison, Duncan, Correa, Okaka, Bergessio, Soriano, Coda, Djordjevic, Marchionni, Wszolek
Cagliari: Brkic; Gonzalez, Rossettini, Capuano, Avelar; Dessena, Cossu, Crisetig; Farias, Longo, M’Poku
Cagliari bench: Colombi, Cragno, Murru, Pisano, Caio Rangel, Barella, Husbauer, Sau, Ceppitelli, Diakité, Cop