Paulo Dybala and Franco Vazquez take on Gregoire Defrel as Palermo visit Cesena in the lunch-time game.
It kicks off at 11.30 GMT, click here for a match preview.
Both teams were promoted from Serie B over the summer, but have enjoyed very different fortunes in the top flight so far.
While Cesena have struggled and remain in the bottom two, Palermo beat the likes of Milan and Napoli to enter into European contention.
Paulo Dybala and Franco Vazquez take on Gregoire Defrel as Palermo visit Cesena in the lunch-time game.
It kicks off at 11.30 GMT, click here for a match preview.
Both teams were promoted from Serie B over the summer, but have enjoyed very different fortunes in the top flight so far.
While Cesena have struggled and remain in the bottom two, Palermo beat the likes of Milan and Napoli to enter into European contention.
The Rosanero are forced into a revamp at the back after injuries to Michel Morganella – whose season is over following knee surgery – Giancarlo Gonzalez, Achraf Lazaar and the suspended Andrea Rispoli.
As ever, Dybala and Vazquez lead the attack, while Edgar Barreto returns from his ban in midfield.
Cesena have been on vastly improved form recently, especially on home turf, holding Juventus to a 2-2 draw and beating Lazio and Udinese.
Daniele Capelli is suspended with Guido Marilungo, Andrea Tabanelli, Ze Eduardo, Luca Valzania and Francesco Renzetti sidelined.
It is a special game for Franco Brienza, who is a former Palermo player now pulling the strings at Cesena for the pacey striker Defrel.
Cesena: Leali; Perico, Lucchini, Krajnc, Magnusson; Giorgi, De Feudis, Mudingayi; Brienza; Defrel, Djuric
Cesena bench: Agliardi, Bressan, Nica, Carbonero, Rodriguez, Volta, Succi, Mordini, Moncini, Cascione, Pulzetti
Palermo: Sorrentino; Vitiello, Terzi, Andelkovic, Daprelà; Rigoni, Jajalo, Barreto; Quaison, Vazquez; Dybala
Palermo bench: Ujkani, Fulignati, Milanovic, Joao Silva, Emerson, Della Rocca, Bolzoni, Chochev, Ortiz, Maresca, Bentivegna, Belotti