Milan named their squad against Fiorentina, missing Philippe Mexes, Jeremy Menez and M’Baye Niang.
It kicks off at the Stadio Artemio Franchi on Sunday at 19.45 UK time (18.45 GMT), click here for a match preview.
The French trio of Mexes, Menez and Niang are all on the treatment table, but Antonio Nocerino is included despite being on the verge of a transfer to Sampdoria.
Alessio Romagnoli can make his competitive Rossoneri debut, while Carlos Bacca and Luiz Adriano are expected to start in attack.
Milan squad for Fiorentina: Abbiati, Donnarumma, Diego Lopez; Abate, Alex, Antonelli, Calabria, Rodrigo Ely, De Sciglio, Paletta, Romagnoli, Zapata; Bertolacci, Bonaventura, De Jong, Jose Mauri, Nocerino, Montolivo, Poli, Suso; Bacca, Cerci, Honda, Luiz Adriano, Matri