Carlos Bacca and Luiz Adriano start for Sinisa Mihajlovic’s Milan at Fiorentina, while Nikola Kalinic gets his Viola debut.
It kicks off at 19.45 UK time (18.45 GMT), click here for to follow the LIVEBLOG of all seven Sunday night games.
This is a huge initial test for new Coach Mihajlovic and is against his former club, having never quite bonded with the Viola supporters.
He has Serie A newcomers Bacca and Luiz Adriano in his starting XI, while €25m defender Alessio Romagnoli leads the back four.
Jeremy Menez, M’Baye Niang and Philippe Mexes are sidelined, but Andrea Bertolacci features in midfield.
Fiorentina boss Paulo Sousa confirmed he had “a lot of problems” this week, as Joaquin is pushing for a transfer, Giuseppe Rossi isn’t fully fit yet and Mario Suarez almost couldn’t play.
There was confusion over whether a red card for Atletico Madrid in the Copa del Rey meant he’d be suspended for Serie A or the Coppa Italia, but on Saturday evening he was given the all-clear.
Nonetheless, he’s on the bench and ex-Dnipro striker Kalinic gets the nod ahead of Khouma Babacar.
Fiorentina: Tatarusanu; Roncaglia, G Rodriguez, Tomovic; Gilberto, Borja Valero, Badelj, Alonso; Bernardeschi, Ilicic; Kalinic
Milan: Diego Lopez; De Sciglio, Ely, Romagnoli, Antonelli; Bertolacci, De Jong, Bonaventura; Honda; Bacca, Adriano