Follow all the build-up and action as it happens from Frosinone v Roma and Fiorentina v Genoa.
They both kick off at 17.00 UK time (16.00 GMT), click here for individual Serie A match previews.
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Roma are fresh from a triumphant result against Juventus, but will they trip up in this first ever edition of the local derby?
Fiorentina and Genoa are two attacking sides, so their encounter at the Stadio Franchi ought to be quite a ride.