Napoli aim to continue their unstoppable streak and take no chances with a full-strength side against Palermo.
It kicks off at 19.45 GMT, follow the action from all eight Serie A games on our LIVEBLOG.
Maurizio Sarri’s men are on stunning form, winning eight of their last nine games in all competition with 25 goals scored and three conceded.
Napoli aim to continue their unstoppable streak and take no chances with a full-strength side against Palermo.
It kicks off at 19.45 GMT, follow the action from all eight Serie A games on our LIVEBLOG.
Maurizio Sarri’s men are on stunning form, winning eight of their last nine games in all competition with 25 goals scored and three conceded.
They climbed into joint second place at the weekend and are targeting top spot as they host a revived Palermo, fresh from a victory and a 1-1 draw with Inter.
With a full squad to choose from, Sarri only rests Kalidou Koulibaly and Allan, starting the usual Gonzalo Higuain, Lorenzo Insigne and Jose Callejon.
The Sicilians go with Alberto Gilardino and Franco Vazquez up front, missing Francesco Bolzoni, Michel Morganella and Uros Djurdjevic.
Palermo have only ever won this fixture once, 2-1 back in December 1951, along with five draws and 15 defeats.
Last season Napoli lost 3-1 in Sicily and were held to an epic 3-3 draw at the San Paolo.
This is traditionally a high-scoring fixture with a total 11 goals in the last three meetings here.
Napoli: Reina; Hysaj, Albiol, Chiriches, Ghoulam; David Lopez, Jorginho, Hamsik; Callejon, Higuain, Insigne
Napoli bench: Rafael, Gabriel, Strinic, Henrique, Allan, Valdifiori, Maggio, Mertens, Gabbiadini, Koulibaly, El Kaddouri, Chalobah
Palermo: Sorrentino; Struna, Gonzalez, Andelkovic; Rispoli, Rigoni, Maresca, Hiljemark, Lazaar; Vazquez, Gilardino
Palermo bench: Colombi, Vitiello, Goldaniga, Trajkovski, Brugman, Chochev, Quaison, Jajalo, Daprelà, El Kaoutari, La Gumina, Pezzella