Roma have Daniele De Rossi back with Edin Dzeko and Mohamed Salah in a must-win Champions League game with Bayer Leverkusen.
It kicks off at the Stadio Olimpico at 19.45 GMT, follow the build-up and action as it happens in our LIVEBLOG.
The Giallorossi are bottom of their group after holding Barcelona to a draw, losing at BATE Borisov and their extraordinary 4-4 thriller at Leverkusen.
Roma have Daniele De Rossi back with Edin Dzeko and Mohamed Salah in a must-win Champions League game with Bayer Leverkusen.
It kicks off at the Stadio Olimpico at 19.45 GMT, follow the build-up and action as it happens in our LIVEBLOG.
The Giallorossi are bottom of their group after holding Barcelona to a draw, losing at BATE Borisov and their extraordinary 4-4 thriller at Leverkusen.
In that game they were 2-0 down, fought back to lead 4-2 and threw that all away in the final minutes.
Both Coaches said they’ll go on the attack so we should have more fireworks on show in the Italian Capital.
De Rossi returns from injury in the starting XI and Alessandro Florenzi moves to right-back after a few games in midfield, even though he is not 100 per cent fit.
Dzeko, Salah and Gervinho lead the attack, as Francesco Totti and Kevin Strootman are still injured.
Rudi Garcia is under a lot of pressure after losing the top of the Serie A table clash to Inter and failing to win a Champions League game for 14 months.
With city rivals Lazio coming up on Sunday, there really is no time to lose.
Bayer Leverkusen are without Tin Jedvaj, Roberto Hilbert and Seung-Woo Ryu, while Lars Bender is out with an ankle problem.
Hakan Calhanoglu will pull the strings and Javier ‘Chicharito’ Hernandez is finding form with six goals in his last four games, but centre-forward Stefan Kiessling returns after missing the first leg.
Bayer already visited the Olimpico in August for the Champions League preliminary round and were beaten 1-0 by Lazio, eventually qualifying with a 3-0 home victory.
‘The Aspirins’ won on Italian soil only once, in 1999 at Udinese, drawing three and losing four. This term they lost both their European away fixtures, scoring only once.
Like Roma, Leverkusen also lost domestically at the weekend, 2-1 away to Wolfsburg.
Roma: Szczesny; Florenzi, Manolas, Rudiger, Digne; Pjanic, De Rossi, Nainggolan; Salah, Dzeko, Gervinho
Roma bench: De Sanctis, Castan, Maicon, Torosidis, Iturbe, Iago Falque, Vainqueur
Bayer Leverkusen: Leno; Donati, Tah, Papadopoulos, Wendell; Kampl, Omer Toprak; Mehmedi, Hakan Calhanoglu; Hernandez, Kiessling
Bayer Leverkusen bench: Kresic, Andre Ramalho, Boenisch, Brandt, Kramer, Yurchenko, Bellarabi