Carlos Bacca and M’Baye Niang lead the line for Milan, as they visit Sampdoria in the Coppa Italia.
The match could be a crucial one for the future of Coach Sinisa Mihajlovic, with President Silvio Berlusconi unhappy with the team’s performances so far.
The Serbian has opted for a 4-4-2 system, with Giacomo Bonaventura supporting Bacca and Niang.
Veteran goalkeeper Christian Abbiati comes in for Gianluigi Donnarumma, while Philippe Mexes is given a chance to impress in central defence.
For the hosts, Antonio Cassano is dropped after an ineffective showing against Lazio on Monday, with Luis Muriel taking his place.
Sampdoria: Viviano; Cassani, Moisander, Zukanovic, Regini; Ivan, Fernando, Carbonero; Soriano; Muriel, Bonazzoli
Sampdoria bench: Brignoli, Puggioni, Coda, De Silvestri, Mesbah, Pereira, Correa, Palombo, Rocca, Lazaros, Rodriguez, Cassano
Milan: Abbiati; Abate, Mexes, Romagnoli, De Sciglio; Cerci, Kucka, Bertolacci, Bonaventura; Bacca, Niang
Milan bench: Donnarumma, Livieri, Antonelli, Calabria, Simic, Zapata, De Jong, Josè Mauri, Poli, Montolivo, Suso, Honda, Luiz Adriano