Jeremy Menez is a surprise inclusion in the Milan squad to face Inter, but Luiz Adriano, Nigel de Jong and Antonio Nocerino miss out.
It kicks off on Sunday at 19.45 GMT, click here for a match preview.
Menez has been out of action all season with on-going injury problems and was not expected to be included, but Sinisa Mihajlovic brings him along for the Derby della Madonnina.
De Jong and Nocerino are absent, most likely so they can be free to negotiate imminent transfers to the American MLS.
Luiz Adriano suffered a knock in training and hasn’t recovered in time, while Diego Lopez, Philippe Mexes and Rodrigo Ely are also injured.
Milan squad for Inter: Abbiati, Donnarumma, Livieri; Abate, Alex, Antonelli, Calabria, De Sciglio, Romagnoli, Simic, Zapata; Bertolacci, Bonaventura, José Mauri, Kucka, Montolivo, Poli; Bacca, Balotelli, Boateng, Honda, Menez, Niang