Jack Bonaventura returns for Milan, but Genoa lose Cristian Ansaldi, Leonardo Pavoletti and Tomas Rincon.
It kicks off on Sunday at 11.30 GMT, click here for a match preview.
The Rossoneri have Bonaventura back in the side after his injury lay-off in the 1-1 draw with Udinese.
M’Baye Niang also took part in today’s full training session and could therefore start rather than Mario Balotelli.
However, there are concerns over Ignazio Abate, who trained separately with an ankle problem.
As for Genoa, Gian Piero Gasperini has to once again do without a series of top players for this trip to San Siro.
Top scorer Pavoletti is out of action for three weeks, joined on the treatment table by Ansaldi and the suspended Rincon.
Ezequiel Munoz is included, but it remains to be seen if he’ll be fit enough to start in defence.
Curiously, both teams have a goalkeeper from the Donnarumma family in the side, as Alfredo is 16-year-old Gianluigi’s older brother.
Suso and Alessio Cerci visit the club they left on loan in January, while Niang and Andrea Bertolacci played for Genoa last season.
Milan squad for Genoa: Abbiati, Donnarumma, Livieri; Alex, Antonelli, Calabria, De Sciglio, Romagnoli, Simic, Zapata; Bertolacci, Bonaventura, Locatelli, Montolivo, Poli; Bacca, Balotelli, Boateng, Luiz Adriano, Honda, Menez, Niang
Genoa squad for Milan: Perin, De Maio, Izzo, Burdisso, Cerci, Marchese, Capel, Suso, Ntcham, Pandev, Lazovic, Lamanna, Munoz, Fiamozzi, Rigoni, Dzemaili, Donnarumma, Gabriel Silva, Matavz, Tachtsidis, Laxalt